Satiatrim

Willpower in a glass

satiatrim: Information for dieticians, nutritionists,

and diet doctors

Your patient has taken an important first step in getting control of her weight. Satiatrim can be a valuable adjunct to a weight-loss program that includes diet resolution an exercise. PacificHealth Laboratories (PHLI), the makers of Satiatrim, advises consumers that any weight reduction program is best done under the guidance of a personal physician. This overview is designed to provide you with information about Satiatrim.

WHAT IS Satiatrim?

Satiatrim is a ready-to-drink beverage whose patented nutritional formula is proven to slow the movement of food from the stomach by activating two important satiety peptides: cholecystokinin (CCK) and PYY. In development for over 10 years, Satiatrim has been shown to: - Slow gastric emptying up to 66% - Reduce the feeling of hunger up to 4 hours - Reduce caloric intake up to 20%

WHAT DOES Satiatrim CONTAIN?

The active ingredients in Satiatrim are long-chain fatty acids, protein, calcium, the amino acid glutamine and green tea extract. Each 8-ounce serving of Satiatrim provides 2 grams of soy protein, 2 grams of fiber, calcium, and an abundant supply of antioxidants (provided by the green tea extract). One serving of Satiatrim has 50 calories or fewer. Satiatrim does not contain any sugar. Additionally, each serving of Satiatrim contains 60 mg of caffeine (or roughly the amount found in a cup of coffee).

WHAT MAKES Satiatrim DIFFERENT?

Satiatrim represents the culmination of research that began more than 40 years ago, when scientists at Columbia and Cornell Universities demonstrated that injection of CCK drastically reduced the rate of gastric emptying and therefore enhanced satiety and reduced caloric intake. Subsequent research has shown that certain nutrients such as protein and fat are potent stimulators of CCK. Based on these findings researchers at PHLI embarked on a program to develop a nutritional formula that could stimulate CCK and other satiety peptides in a calorically efficient manner. This research led to the development of Satiatrim - a novel combination of soy and casein proteins, calcium, and unsaturated fats. The Satiatrim formula was shown to be extremely effective in stimulating CCK. Satiatrim also contains glutamine, which stimulates PYY, as well as catechins from green tea, which produce a mild thermogenic effect.

HOW CAN PATIENTS LOSE WEIGHT WITH Satiatrim?

As any medical professional knows, there are no magic bullets for helping patients lose weight. Long-term success requires a decrease in caloric intake and an increase in activity. All too often, however, when patients reduce their caloric intake they feel hungry, compliance drops and the weight loss/weight regain cycle continues. By helping your patients feel less hungry when consuming a calorie restricted diet, Satiatrim improves compliance.

HOW SHOULD Satiatrim BE USED?

For optimum results, your patients should use Satiatrim before they eat. Consume one 8 ounce serving before breakfast, lunch, and/or dinner. They can also take Satiatrim as a midmorning snack and/or an evening snack. Daily servings of Satiatrim can be based off personal needs.

HAVE THEIR BEEN MANY STUDIES CONDUCTED ON Satiatrim?

PacificHealth Laboratories has conducted more than 15 controlled trials measuring the effect of Satiatrim on caloric intake, on movement of food from the stomach, and on the duration of the feeling of fullness after a meal. PHLI researchers have also shown that Satiatrim stimulates the body's feel-full protein, cholecystokinin. Specifically, these studies demonstrate that Satiatrim reduces food intake by up to 20% and extends the feeling of fullness for up to four hours after a meal. Some of the data have been presented at major obesity research meetings. PHLI is in the process of applying for additional patents on the product and until these are filed we will not submit the data for publication. We have received five patents to date on this technology and its ability to reduce appetite.

HOW LONG DOES IT TAKE FOR Satiatrim TO WORK?

Your patient will feel the effect of Satiatrim immediately. IT has also been shown that the effectiveness of Satiatrim actually increases as the patient loses weight. A normal consequence with using Satiatrim is a reduction in fat intake. Research has shown that as individuals reduce their fat intake their body becomes even more sensitive to the hunger-reducing effects of satiety peptides.

WHAT TYPE OF DIETARY GUIDANCE IS PROVIDED TO Satiatrim CONSUMERS?

PacificHealth Laboratories has created the Satiatrim Success Plan to help patients lose weight safely and effectively with Satiatrim.

ARE THERE ANY CONTRAINDICATIONS WITH Satiatrim?

The major contraindication would be allergy to any of Satiatrim's ingredients, principally soy and casein (milk protein). Satiatrim does not contain lactose.

ARE THERE ANY POTENTIAL SIDE EFFECTS?

Most people do not experience side effects with Satiatrim. However, individuals who are not used to consuming significant fiber in their diet (each serving of Satiatrim contains two grams of fiber) may experience mild constipation, which usually subsides after a week.

Click on the following link to download a Satiatrim information sheet for physicians and other health professionals. We encourage you to print and take this document to your doctor, registered dietician, or any other healthcare professional who is guiding your weight loss efforts. The document is saved as a PDF file and requires Adobe Acrobat reader to be viewed.

Healthy Weight loss with Satiatrim

Have you ever wondered why some foods make you feel fuller than others? The main reason is that certain foods move more slowly through the stomach. The slower your stomach empties, the fuller you feel. Satiatrim is the first diet product that increases fullness by slowing the movement of food in your stomach, so you feel fuller with less food and lose weight.

Most people know intuitively that feelings of fullness are generated from the stomach. When you eat, your stomach distends, or stretches. The distension of your stomach activates your appetite control switch, which tells you to stop eating and diminishes hunger until it is time to eat again. This is how your appetite switch is turned off. When food enters your stomach it stimulates the release of a protein called cholecystokinin, or CCK. When CCK is released, the first thing it does is close down the valve from the stomach into the GI tract. This slows the movement of food from the stomach, producing a feeling of fullness, or satiety. Because of its effects, CCK is sometimes referred to as the "feel-full" protein.

The unique properties of CCK were discovered over 40 years ago when researchers at Cornell and Columbia universities demonstrated that injecting CCK into humans reduced appetite up to 20%. In the last 40 years there have been thousands of studies showing the effectiveness of CCK in controlling appetite.

When the Appetite Control Switch Doesn't Work

The appetite control switch was designed to work best with the natural foods that humans ate exclusively thousands of years ago. Many of the processed foods we eat today are far more calorically dense than those natural foods, meaning they contain more calories in less space.

According to Dr. Steven Peikin, Professor of Medicine, Cooper Union University Hospital, and author of The Complete Book of Diet Drugs, "Unfortunately, these processed foods enable us to eat more calories than our bodies need before the appetite control switch gets activated. It is not unusual for an individual to eat a fast food meal of 1,000 calories in less than 10 minutes. But it takes more than 10 minutes for food to stimulate enough CCK to make you stop eating. Thus, when you eat high-calorie processed foods, you can easily overeat before CCK begins to work and you feel full."

To make matters worse, as we become overweight, our excess fat contributes to the problem because people who are overweight have a less sensitive response to CCK.

The Search for a New and Different Weight Loss Product

Ever since the feel-full protein was first discovered, scientists have searched for ways to create a weight loss product that would stimulate CCK, slow the movement of food in the stomach, and produce fullness with minimal calories. That search culminated in the development of Satiatrim, a 50-calorie sugar-free beverage containing a patented combination of specific proteins, a small amount of fatty acids and calcium. Multiple studies have shown that Satiatrim works by releasing CCK. Drinking Satiatrim before a meal—even a fast-food meal—turns off your appetite control switch before you start eating so you feel fuller even though you are eating less. The action of Satiatrim also keeps you hunger-free until you eat again. And because Satiatrim restores your body's natural gastric pacing, it makes any healthy weight loss plan more effective.

Clinical Proof

The nutritional technology on which Satiatrim is based has been extensively tested over the last ten years. The technology has received five patents with additional ones pending. These studies have focused on how Satiatrim works and on its effect on appetite and caloric intake. A number of these studies have already been published and a new study conducted at the University of Manchester in Manchester, England will be presented at this year's meeting of the North American Association for the Study of Obesity. These studies show:

• Satiatrim decreases caloric intake up to 20%
• The effect of Satiatrim is mediated through CCK
• Satiatrim extends the feeling of fullness for up to four hours after eating a fixed-calorie meal
• Satiatrim reduces gastric emptying by up to 66% (see chart)

The long search for a healthy and effective weight loss product is over. Satiatrim is the first diet product proven to enhance fullness and reduce eating by slowing the movement of food in the stomach. And the best thing about Satiatrim is that it works with any type of food, so it makes any diet more effective.

Studies